Open preprints for single-subject science
nof1xiv is an open archive where patient-scientists share n-of-1 experiments — careful tests you ran on yourself — as citable preprints. Write in plain Markdown. Get a permanent ID. Let others learn from what you found.
Pick one thing to change and one or two things to measure. Track it over time — ideally with periods on and off.
Use our friendly template. Describe what you did, show your data, and say what you concluded — no jargon required.
Your study gets a permanent nof1xiv ID and a citation other people can reference. Revise it anytime.
Jordan Reyes
Over 12 weeks I alternated 3-week blocks of nightly magnesium glycinate with 3-week blocks of nothing. Migraine days dropped from ~3/week off magnesium to ~1.5/week on it. Encouraging, but unblinded and confounded by better sleep.
Mara Okafor
I tested whether 10 minutes of outdoor light within 30 minutes of waking would reduce my afternoon energy crashes over 6 weeks. The crashes got modestly better, but the effect was smaller than I expected and faded on cloudy days.