About nof1rxiv

nof1rxiv is an open archive for n-of-1 experiments — studies with a sample size of one. Most of the time, the one subject is the author: a person trying to find out whether something actually helps them.

What is an n-of-1 experiment?

It's a careful test you run on yourself. Instead of guessing whether a supplement, diet, sleep change, or routine is working, you change one thing, measure one or two outcomes over time, and look at what happened — ideally comparing periods when you were doing the thing against periods when you weren't.

Clinicians and researchers use formal n-of-1 trials for exactly this reason. You don't need a lab — you need a clear question, honest measurement, and a willingness to share what you found, including when it didn't work.

Why share it as a preprint?

A preprint is a research write-up shared openly before formal peer review. arXiv and bioRxiv made this normal for physics and biology. nof1rxiv does the same for personal experiments: your study gets a permanent ID and a citation, so others can find it, learn from it, build on it, or try to replicate it.

What this is not

• Not peer reviewed. Studies here are self-reported and unverified. Read them critically.
• Not medical advice. Nothing here should replace a conversation with a qualified clinician.
• Not a place for others' data. Publish your own experiments. Don't post identifiable information about anyone who hasn't consented.

Our principles

• Honesty over hype. Null and negative results are welcome and valuable.
• Show your work. Describe your method and share your data when you can.
• Open by default. Studies are published under open licenses (typically CC BY 4.0) so knowledge can spread.