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nof1rxiv:2026.0002preprint·2 min read

Does 400 mg magnesium glycinate at night reduce my migraine days?

Jordan Reyes

Posted June 18, 2026

Preprint — not peer reviewed. This is a self-reported, single-subject experiment shared by its author. It has not been verified and is not medical advice. Talk to a qualified clinician before changing anything about your health.

Summary

Over 12 weeks I alternated 3-week blocks of nightly magnesium glycinate with 3-week blocks of nothing. Migraine days dropped from ~3/week off magnesium to ~1.5/week on it. Encouraging, but unblinded and confounded by better sleep.

Background

I get 2–4 migraine days most weeks. A neurologist mentioned magnesium as a low-risk thing some people try, so I decided to test it on myself properly rather than just "see how it goes."

Method

I used an ABAB design: alternating 3-week blocks with no magnesium (A) and 3 weeks of 400 mg magnesium glycinate taken ~30 minutes before bed (B). I kept a simple headache diary in my notes app every morning, logging whether I had a migraine the previous day and, if so, the peak pain on a 0–10 scale.

I tried to keep everything else constant — caffeine, work schedule, screen habits — though life isn't a lab.

Results

PhaseWeeksMigraine days/weekMean pain on migraine days
A (off)1–33.06.4
B (on)4–61.75.8
A (off)7–92.76.1
B (on)10–121.35.2

Averaged across blocks, migraine days fell from 2.85/week off to 1.5/week on — roughly a 47% reduction. Pain intensity dropped only slightly.

Discussion

The on/off pattern repeating twice makes me more confident this isn't pure chance. But there are real limitations:

  • Unblinded. I knew which phase I was in, so expectation effects are likely.
  • Sleep confound. Magnesium seemed to improve my sleep, and poor sleep is one of my migraine triggers — so the effect may be indirect.
  • Short blocks. 3 weeks is not long; a single bad week swings the average.

Conclusion

For me, nightly magnesium glycinate is associated with meaningfully fewer migraine days, and the cost/risk is low enough that I'm continuing it. I would not generalize this to anyone else — but I'd love for someone to try a blinded version (e.g., identical-looking capsules) and post their results here.

Cite this study

Jordan Reyes (2026). Does 400 mg magnesium glycinate at night reduce my migraine days?. nof1rxiv. nof1rxiv:2026.0002. https://nof1rxiv.org/study/magnesium-migraine

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